Best Zylkne 450 Mg 2026

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Last Updated - 03.02.2026

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01

Vetoquinol

Zylkene 450 mg 100 gelules

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9.7

Exceptional

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

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Main highlights

α-Casozepine = Zylkène contains natural α-casozepine, an extract obtained by enzymatic cleavage (trypsin) from the milk protein casein from skimmed milk and can have a supportive soothing effect. It is known that newborns and infants convert milk casein into α-casocepine by enzymatic cleavage. This ability to convert milk casein into α-casocepine is lost at about the age of 4 months and with it the calming effect of milk.
Vetoquinol Zylkène 450 mg 100 capsules is a supplementary feed for dogs. Recommended for dogs who are exposed to unfamiliar situations or where events are imminent such as changes in the environment, being left alone, family growth, changing caregivers, keeping several pets, lactation, weaning, travelling, fireworks or for all situations where your pet's usual routine is changed.
Mechanism of action: α-casocepine binds to the so-called γ-aminobutyric acid A (GABA-A) receptor in the central nervous system (CNS), which explains the anxiety-relieving effect as well as with benzodiazepines (psychotropic drugs) often used as a sedative. The effect is therefore similar to that of a benzodiazepine, but the mechanism of action is different. GABAA is a messenger substance of the central nervous system, which has an inhibitory and thus calming effect.
If dogs suffer from stress or anxiety, it is important not to ignore them, but to help the animals immediately. Because stress and anxiety can change the behavior of an animal and destroy its being in the long term. Finally, organ diseases can also develop from continued behavioural disorders. There are various ways to combat stress and anxiety related behaviour disorders and counteract the suffering of animals.
How is Zylkene used? Zylkène can be used alone or in combination with behavioral therapy. Should the causes of anxiety/stress be found in the animal's environment, changing the environment is a possible approach to deprive the animal of its anxiety.

133,90 €
02

Vetoquinol

Zylkene 450 mg 100 gelules

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9.5

Excellent

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Show more
Main highlights

α-Casozepine = Zylkène contains natural α-casozepine, an extract obtained by enzymatic cleavage (trypsin) from the milk protein casein from skimmed milk and can have a supportive soothing effect. It is known that newborns and infants convert milk casein into α-casocepine by enzymatic cleavage. This ability to convert milk casein into α-casocepine is lost at about the age of 4 months and with it the calming effect of milk.
Vetoquinol Zylkène 450 mg 100 capsules is a supplementary feed for dogs. Recommended for dogs who are exposed to unfamiliar situations or where events are imminent such as changes in the environment, being left alone, family growth, changing caregivers, keeping several pets, lactation, weaning, travelling, fireworks or for all situations where your pet's usual routine is changed.
Mechanism of action: α-casocepine binds to the so-called γ-aminobutyric acid A (GABA-A) receptor in the central nervous system (CNS), which explains the anxiety-relieving effect as well as with benzodiazepines (psychotropic drugs) often used as a sedative. The effect is therefore similar to that of a benzodiazepine, but the mechanism of action is different. GABAA is a messenger substance of the central nervous system, which has an inhibitory and thus calming effect.
If dogs suffer from stress or anxiety, it is important not to ignore them, but to help the animals immediately. Because stress and anxiety can change the behavior of an animal and destroy its being in the long term. Finally, organ diseases can also develop from continued behavioural disorders. There are various ways to combat stress and anxiety related behaviour disorders and counteract the suffering of animals.
How is Zylkene used? Zylkène can be used alone or in combination with behavioral therapy. Should the causes of anxiety/stress be found in the animal's environment, changing the environment is a possible approach to deprive the animal of its anxiety.

133,90 €
03

Vetoquinol

Vetoquinol Zylkene Chews 450 mg - 14 Chews

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25% Off
9.2

Excellent

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

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Main highlights

Zylkène Chews are tasty and easy to feed. Feed Zylkene Chews to dogs and cats that are exposed to unfamiliar, stressful situations or who are facing events such as changes in the environment of being left alone, family growth, keeping multiple pets, lactation, weaning, traveling, fireworks or for any situation where your pet's usual routine is changed.
The chews can be fed directly or mixed with the food. Recommended feeding time: 1-2 days before the change or the change of environment occurs. For some animals, an earlier dose proves to be useful (5 - 7 days). In case of severe behavioral problem, please talk to your veterinarian. Clubs that offer special behavioral training can help you.
Large dogs: 15-30 kg: 1 chew daily. 30-60 kg: 2 chews daily
Composition: corn swelling starch, glycerin, yeast extracts, cellulose powder, casein (trypsin hydrolysed cattle casein), acetic acid esters from mono- and diglycerides of fatty acids (based on soybean oil), soybean oil, sunflower oil.
Additives: antioxidant, preservative. Analytical ingredients: crude protein 19.8%, crude fibre 9.3%, moisture 10%, crude fat 8%, crude ash 3.7%.

23,99 € 31,90 €(25% Off off)
Value for Money

04

Vetoquinol

Vetoquinol Zylkene Chews 450 mg - 14 Chews

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26% Off
8.9

Very Good

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Show more
Main highlights

Zylkène Chews are tasty and easy to feed. Feed Zylkene Chews to dogs and cats that are exposed to unfamiliar, stressful situations or who are facing events such as changes in the environment of being left alone, family growth, keeping multiple pets, lactation, weaning, traveling, fireworks or for any situation where your pet's usual routine is changed.
The chews can be fed directly or mixed with the food. Recommended feeding time: 1-2 days before the change or the change of environment occurs. For some animals, an earlier dose proves to be useful (5 - 7 days). In case of severe behavioral problem, please talk to your veterinarian. Clubs that offer special behavioral training can help you.
Large dogs: 15-30 kg: 1 chew daily. 30-60 kg: 2 chews daily
Composition: corn swelling starch, glycerin, yeast extracts, cellulose powder, casein (trypsin hydrolysed cattle casein), acetic acid esters from mono- and diglycerides of fatty acids (based on soybean oil), soybean oil, sunflower oil.
Additives: antioxidant, preservative. Analytical ingredients: crude protein 19.8%, crude fibre 9.3%, moisture 10%, crude fat 8%, crude ash 3.7%.

23,49 € 31,90 €(26% Off off)
05

Zylkene

Zylkene 450 mg, 50 capsules, supplementary feed for large dogs, for support in unusual situations, with trypsin hydrolysed cattle casein

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8.7

Very Good

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

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Main highlights

Use: the easy application can make the gift a small reward for dogs. The capsules can be fed directly or mixed with the food
Stress situation: Zylkene is a supplementary feed for dogs. The Zylkene capsules can help dogs in stressful situations to provide quick relaxation
Loud noises, veterinary visits, moving – for many dogs, loud noises such as New Year's Eve or normal everyday sounds, as well as unusual situations mean stress
Ingredients – Zylkene can help reduce stress. The Zylkene capsules contain natural ingredients that can help reduce stress in dogs
Feeding time: the recommended daily ration should be given complete with one feeding. Recommended feeding time: 1-2 days before the changeover occurs

70,30 €
06

Zylkene

Zylkene 450 mg, 50 capsules, supplementary feed for large dogs, for support in unusual situations, with trypsin hydrolysed cattle casein

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8.5

Good

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Show more
Main highlights

Use: the easy application can make the gift a small reward for dogs. The capsules can be fed directly or mixed with the food
Stress situation: Zylkene is a supplementary feed for dogs. The Zylkene capsules can help dogs in stressful situations to provide quick relaxation
Loud noises, veterinary visits, moving – for many dogs, loud noises such as New Year's Eve or normal everyday sounds, as well as unusual situations mean stress
Ingredients – Zylkene can help reduce stress. The Zylkene capsules contain natural ingredients that can help reduce stress in dogs
Feeding time: the recommended daily ration should be given complete with one feeding. Recommended feeding time: 1-2 days before the changeover occurs

70,30 €
07

Zylkene

Zylkene 450mg - 30 capsules (dogs)

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8.3

Good

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

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Main highlights

Analytical ingredients: crude protein 78%, crude ash 12%, moisture 8%, crude fat 3%, crude fibre 0% additives dyes / dyed with EC additives

45,49 €
08

Zylkene

Zylkene 450mg - 30 capsules (dogs)

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8.1

Good

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

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Main highlights

Analytical ingredients: crude protein 78%, crude ash 12%, moisture 8%, crude fat 3%, crude fibre 0% additives dyes / dyed with EC additives

44,99 €
09

Zylkene

Vetoquinol Zylkene Capsules For Large Dogs, 450 mg, 20-Count

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7.9

Good

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

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Main highlights

Composition CYLKENE 450 mg: casein (trypsin-hydrolysed cattle casein), magnesium stearate powder weight per capsule = 463.5 mg. Content powder: 82.9% capsule (gelatin from bovine skin) 17.1%. Analytical components: crude protein 78%, crude ash 12%. Raw fffett 3%, crude fibre 0% additives dyes / dyed with EC additives

32,00 €
10

Zylkene

Vetoquinol Zylkene Capsules For Large Dogs, 450 mg, 20-Count

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7.7

Good

Our rankings are cleverly generated from the algorithmic analysis of thousands of customer reviews about products, brands, merchant’s customer service level, popularity, trends and more. The rankings reflect our opinion and should be a good starting point for shopping.

Show more
Main highlights

Composition CYLKENE 450 mg: casein (trypsin-hydrolysed cattle casein), magnesium stearate powder weight per capsule = 463.5 mg. Content powder: 82.9% capsule (gelatin from bovine skin) 17.1%. Analytical components: crude protein 78%, crude ash 12%. Raw fffett 3%, crude fibre 0% additives dyes / dyed with EC additives

32,00 €